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Seco Rapamycin sodium salt

Seco Rapamycin sodium salt is a ring-opened product of Rapamycin.

Catalog No. T19558Cas No. 148554-65-8

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Seco Rapamycin sodium salt

Catalog No. T19558Cas No. 148554-65-8

Seco Rapamycin sodium salt is a ring-opened product of Rapamycin.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Pack Size	Price	Availability
1 mg	$295	35 days
5 mg	$1,170	35 days
10 mg	$1,750	35 days

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Questions

Product Introduction

Bioactivity

Description	Seco Rapamycin sodium salt is a ring-opened product of Rapamycin.
In vitro	When applied to the apical compartment, little Seco Rapamycin is detected in the basolateral compartment and in the cellular fraction after 4 h. In addition, little M2 is detected. LY335979 has little effect on the distribution of Seco Rapamycin after an apical dose, although M2 became detectable in the apical compartment. In contrast, when Seco Rapamycin is applied to the basolateral compartment, both Seco Rapamycin and M2 are readily detected in the apical compartment; LY335679 decreases the flux of Seco Rapamycin to the apical compartment and increases the amount of M2 in both apical and basolateral compartments.
Alias	Secorapamycin A monosodium

Chemical Properties

Molecular Weight	937.177
Formula	C₅₁H₇₉NNaO₁₃
Cas No.	148554-65-8

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 46 mg/mL (49.14 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.0670 mL	5.3352 mL	10.6703 mL	53.3517 mL
5 mM	0.2134 mL	1.0670 mL	2.1341 mL	10.6703 mL
10 mM	0.1067 mL	0.5335 mL	1.0670 mL	5.3352 mL
20 mM	0.0534 mL	0.2668 mL	0.5335 mL	2.6676 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

You can also refer to dose conversion for different animals. More

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

Secorapamycin ASeco Rapamycin sodiumSeco Rapamycin sodium salt