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Semaglutide TFA

Name: Semaglutide TFA
Brand: TargetMol
SKU: T12878
Price: 232 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T12878

Alias Semaglutide TFA (910463-68-2 free base)

Semaglutide TFA is a glucagon-like peptide-1 congener that induces weight loss, lowers blood glucose levels, and reduces cardiovascular risk in diabetic patients.Semaglutide TFA induces mild-to-moderate and transient gastrointestinal disturbances, and may be used in the study of type 2 diabetes and obesity.

Semaglutide TFA

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Purity: 99.69%

Catalog No. T12878Alias Semaglutide TFA (910463-68-2 free base)

Pack Size	Price	Availability	Quantity
1 mg	$232	In Stock
5 mg	$803	Backorder

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Purity:99.69%

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COA

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Product Introduction

Bioactivity

Description	Semaglutide TFA is a glucagon-like peptide-1 congener that induces weight loss, lowers blood glucose levels, and reduces cardiovascular risk in diabetic patients.Semaglutide TFA induces mild-to-moderate and transient gastrointestinal disturbances, and may be used in the study of type 2 diabetes and obesity.
Targets&IC50	GLP1 receptor:0.38 nM (Kd)
In vitro	Semaglutide TFA is a modified GLP-1 analog with two substitutions (Aib and Arg) at amino acids 8 and 34 and a chemical modification of the lysine at position 26 compared to human GLP-1. It has an affinity for the GLP-1 receptor of 0.38 nM. [1] The amino acid sequence of Semaglutide TFA shares 94% homology with human GLP-1. [3]
In vivo	The plasma half-life of Semaglutide TFA was 46 hours after intravenous injection and the mean retention time (MRT) was 63.6 hours after subcutaneous injection in a small pig study.[1] Semaglutide TFA significantly ameliorated dyskinesia induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). In addition, it protects dopaminergic neurons in the brain by restoring tyrosine hydroxylase (TH) levels, attenuating inflammatory responses, reducing lipid peroxidation, inhibiting apoptosis and promoting the expression of autophagy-related proteins. Semaglutide TFA shows better results in most aspects compared to liraglutide. [2] Semaglutide TFA lowers blood glucose by promoting insulin secretion and is also effective in reducing body weight. [3]
Alias	Semaglutide TFA (910463-68-2 free base)

Chemical Properties

Molecular Weight	4225.6482
Formula	C₁₈₉H₂₉₀F₃N₄₅O₆₁
Smiles	CC[C@@H]([C@@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@H](C(NCC(O)=O)=O)CCCNC(N)=N)=O)=O)CCCNC(N)=N)=O)C(C)C)=O)CC(C)C)=O)Cc(cn1)c2c1cccc2)=O)C)=O)NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC(CNC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](C(C)C)NC([C@@H](NC([C@@H](NC([C@H]([C@H](O)C)NC([C@@H](NC([C@H]([C@H](O)C)NC(CNC([C@@H](NC(C(C)(NC([C@H](Cc3ncnc3)N)=O)C)=O)CCC(O)=O)=O)=O)=O)Cc4ccccc4)=O)=O)CO)=O)CC(O)=O)=O)=O)CO)=O)CO)=O)Cc5ccc(O)cc5)=O)CC(C)C)=O)CCC(O)=O)=O)=O)CCC(N)=O)=O)C)=O)C)=O)CCCCNC(COCCOCCNC(COCCOCCNC(CC[C@H](C(O)=O)NC(CCCCCCCCCCCCCCCCC(O)=O)=O)=O)=O)=O)=O)CCC(O)=O)=O)Cc6ccccc6)=O)C.OC(C(F)(F)F)=O
Relative Density.	no data available

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

H2O: 80 mg/mL (18.93 mM), Sonication is recommended.

DMSO: 80 mg/mL (18.93 mM), Sonication is recommended.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	0.2367 mL	1.1833 mL	2.3665 mL	11.8325 mL
5 mM	0.0473 mL	0.2367 mL	0.4733 mL	2.3665 mL
10 mM	0.0237 mL	0.1183 mL	0.2367 mL	1.1833 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

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