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Seneciphylline N-oxide

Name: Seneciphylline N-oxide
Brand: TargetMol
SKU: TN2204
Price: 32 USD
Availability: InStock
Rating: 4.5 (1 reviews)

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Catalog No. TN2204Cas No. 38710-26-8

Seneciphylline N-oxide is a pyrrolizidine alkaloid obtained from Emilia sonchifolia and is the dehydrogenation product of Senecionine N-oxide.

Seneciphylline N-oxide

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Catalog No. TN2204Cas No. 38710-26-8

Seneciphylline N-oxide is a pyrrolizidine alkaloid obtained from Emilia sonchifolia and is the dehydrogenation product of Senecionine N-oxide.

Pack Size	Price	Availability	Quantity
5 mg	$1,890	Backorder
1 mL x 10 mM (in DMSO)	$2,289	Backorder

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Product Introduction

Bioactivity

Description	Seneciphylline N-oxide is a pyrrolizidine alkaloid obtained from Emilia sonchifolia and is the dehydrogenation product of Senecionine N-oxide.
In vitro	Root cultures of Senecio erucifolius (Asteraceae) efficiently took up and incorporated [14C]putrescine and [14C]arginine into the pyrrolizidine alkaloid (PA) senecionine N-oxide. Pulse-chase experiments covering a growth period of 10 to 19 days revealed the absence of any significant alkaloid turnover[1]
In vivo	Seneciphylline was quickly absorbed into plasma (Tmax , 0.23-0.32 h) and reached the maximum concentration of 0.82-1.75 μg/mL after oral administration. Both seneciphylline and seneciphylline N-oxide were eliminated from plasma quickly. The low system exposure (oral bioavailability, 5.43-10.31%) was related to the extensive metabolism in the liver and microflora.[2]

Chemical Properties

Molecular Weight	349.38
Formula	C₁₈H₂₃NO₆
Cas No.	38710-26-8
Smiles	[O-][N+]12[C@]3([C@@]([H])(CC2)OC(/C(CC([C@@](C(OCC3=CC1)=O)(C)O)=C)=C\C)=O)[H]
Relative Density.	1.31g/cm3

Storage & Solubility Information

Storage

store at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

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Keywords

Seneciphylline NoxideSeneciphylline N oxideSeneciphylline N-oxide