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SGK1-IN-1

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Catalog No. T12890Cas No. 1279829-87-6

SGK1-IN-1 is a highly active and selective SGK-1 inhibitor with an IC50 of 1 nM.

SGK1-IN-1

SGK1-IN-1

😃Good
Catalog No. T12890Cas No. 1279829-87-6
SGK1-IN-1 is a highly active and selective SGK-1 inhibitor with an IC50 of 1 nM.
Pack SizePriceAvailabilityQuantity
2 mg$2335 days
5 mg$2975 days
25 mg$9876-8 weeks
50 mg$1,3606-8 weeks
100 mg$1,8606-8 weeks
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Product Introduction

Bioactivity
Description
SGK1-IN-1 is a highly active and selective SGK-1 inhibitor with an IC50 of 1 nM.
Targets&IC50
SGK1:1 nM
In vitro
SGK1-IN-1 (14n) demonstrates favorable SGK isoform selectivity, exhibiting potent activity towards hSGK2 and moderate activity against hSGK3, with IC50 values of 1 and 41 nM at ATP concentrations of 10 μM and 50 μM, respectively. Additionally, it shows cellular efficacy by inducing SGK1-dependent phosphorylation of GSK3β in U2OS cells, achieving an activity level of 0.69 μM[2].
Chemical Properties
Molecular Weight418.83
FormulaC17H12ClFN6O2S
Cas No.1279829-87-6
Relative Density.1.646 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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Keywords

SGK1IN1SGK1 IN 1SGK-1-IN-1SGK1-IN-1
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