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SH-42

Name: SH-42
Brand: TargetMol
SKU: T36536
Price: 214 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T36536Cas No. 2143952-36-5

SH-42 is a human Δ24-dehydrocholesterol reductase (DHCR24) inhibitor (IC50: 42 nM) that is selective and highly potent in inducing an increase in plasma desmethylferricinol levels.

SH-42

🥰Excellent

Catalog No. T36536Cas No. 2143952-36-5

SH-42 is a human Δ24-dehydrocholesterol reductase (DHCR24) inhibitor (IC50: 42 nM) that is selective and highly potent in inducing an increase in plasma desmethylferricinol levels.

Pack Size	Price	Availability	Quantity
2 mg	$214	In Stock

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Purity:≥98%

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COA HNMR

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Product Introduction

Bioactivity

Description	SH-42 is a human Δ24-dehydrocholesterol reductase (DHCR24) inhibitor (IC50: 42 nM) that is selective and highly potent in inducing an increase in plasma desmethylferricinol levels.
Targets&IC50	DHCR24:42 nM

Chemical Properties

Molecular Weight	402.57
Formula	C₂₅H₃₈O₄
Cas No.	2143952-36-5
Smiles	C[C@@]12[C@@]3(C([C@]4([C@](C)(CC3)[C@@]([C@@H](COC=O)C)(CC4)[H])[H])=CC[C@]1(C[C@@H](OC(C)=O)CC2)[H])[H]

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 1 mg/mL (2.48 mM), Sonication is recommended.

Chloroform: 10 mg/mL (24.84 mM), Sonication is recommended.

Solution Preparation Table

DMSO/Chloroform

	1mg	5mg	10mg	50mg
1 mM	2.4840 mL	12.4202 mL	24.8404 mL	124.2020 mL

Chloroform

	1mg	5mg	10mg	50mg
5 mM	0.4968 mL	2.4840 mL	4.9681 mL	24.8404 mL
10 mM	0.2484 mL	1.2420 mL	2.4840 mL	12.4202 mL
20 mM	0.1242 mL	0.6210 mL	1.2420 mL	6.2101 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

SH-42SH42SH 42DHCR24