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SHLP-3

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Catalog No. TP2783

SHLP-3, a mitochondrial-derived peptide encoded by the 16S ribosomal RNA gene (MT-RNR2), enhances cellular vitality and reduces cell death (apoptosis) in NIT-1β insulinoma cells and 22Rv1 human prostate cancer cells. This peptide boosts mitochondrial function by increasing mitochondrial oxygen consumption rate (OCR), cellular ATP, and reducing the capacity to produce ROS, thereby providing cellular protection. SHLP-3 is utilized in research on diabetes and cancer.

SHLP-3

SHLP-3

😃Good
Catalog No. TP2783
SHLP-3, a mitochondrial-derived peptide encoded by the 16S ribosomal RNA gene (MT-RNR2), enhances cellular vitality and reduces cell death (apoptosis) in NIT-1β insulinoma cells and 22Rv1 human prostate cancer cells. This peptide boosts mitochondrial function by increasing mitochondrial oxygen consumption rate (OCR), cellular ATP, and reducing the capacity to produce ROS, thereby providing cellular protection. SHLP-3 is utilized in research on diabetes and cancer.
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Questions
QWhether sonication is needed for product dissolution? What if I don't have an ultrasound machine?
Asonication can accelerate dissolution. If the compound is not dissolving, sonication is recommended. If you don't have an ultrasound machine, a lower solvent concentration or using less powder are recommended.
QWhether TargetMol inhibitor products are suitable for industrial use?
AThere are various standards for defining the purity, and we do not have fixed purity standard. The purity of most products are above 98% and can be used for control experiments, including cell experiments, animal experiments, general laboratory experiments, and high-throughput screening. Our product purity also meets the industrial standard.
QHow much inhibitor should be added in cell experiments?
AIt is recommended to refer to literatures of experiments conducted using the same model. In addition, it is also necessary to determine the optimal working concentration (concentration gradient) through pre-experiments by constructing a dose-response curve. Similarly, the optimal incubation time (time gradient) should be determined through a time-course experiment. Moreover, the amount of inhibitor used is influenced by various factors, including the accessibility of the target, cell permeability, incubation time, cell type, and others. We recommend determining the initial concentration of the inhibitor by referring to the literatures. If the Ki or IC50 are reported, it is recommended to start with 5-10 times their reported values to achieve the optimal inhibition of enzyme activity. If the Ki or IC50 are unknown, the inhibitor concentrations should be tested, and the Ki value can be calculated using Michaelis-Menten kinetics. Typically, the solvent used for dissolving the inhibitor is used as a control to eliminate the non-specific effects of the solvent.
QWhat is the calculation method for preparing a solution?
AThe calculation method is as follows: （1） c=n/v=m/M/v Concentration=amount of substance/volume=mass/molar mass/volume (2) The solution preparation table is presented in the the product details page on our website. You can add the volume of solvent as referenced.
QHow long does sonication usually take?
AThe sonication time depends on the amount and concentration of the substance
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Product Introduction

Bioactivity
Description
SHLP-3, a mitochondrial-derived peptide encoded by the 16S ribosomal RNA gene (MT-RNR2), enhances cellular vitality and reduces cell death (apoptosis) in NIT-1β insulinoma cells and 22Rv1 human prostate cancer cells. This peptide boosts mitochondrial function by increasing mitochondrial oxygen consumption rate (OCR), cellular ATP, and reducing the capacity to produce ROS, thereby providing cellular protection. SHLP-3 is utilized in research on diabetes and cancer.
Chemical Properties
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
1 Enter information below:
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2 Enter the in vivo formulation:
% DMSO
%
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%ddH2O

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

References

1.McCabe RT, Newman AH, Skolnick P. AHN 683: a fluorescent ligand for peripheral-type benzodiazepine receptors. J Pharmacol Exp Ther. 1992 Aug;262(2):734-40. PubMed PMID: 1323661.

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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