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SHP836

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Catalog No. T16878Cas No. 1957276-35-5

SHP836 is an inhibitor of SHP2 allosteric (IC50: 12 μM for the full-length SHP2).

SHP836

SHP836

😃Good
Catalog No. T16878Cas No. 1957276-35-5
SHP836 is an inhibitor of SHP2 allosteric (IC50: 12 μM for the full-length SHP2).
Pack SizePriceAvailabilityQuantity
5 mg$3326-8 weeks
25 mg$9876-8 weeks
50 mg$1,3606-8 weeks
100 mg$2,1106-8 weeks
1 mL x 10 mM (in DMSO)$3336-8 weeks
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Product Introduction

Bioactivity
Description
SHP836 is an inhibitor of SHP2 allosteric (IC50: 12 μM for the full-length SHP2).
Targets&IC50
SHP2:12 μM
In vitro
SHP836 stabilizes the active conformation of SHP2, rendering its catalytic site inaccessible to the substrate [1].
Chemical Properties
Molecular Weight352.26
FormulaC16H19Cl2N5
Cas No.1957276-35-5
Relative Density.1.278 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
1 Enter information below:
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2 Enter the in vivo formulation:
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

SHP 836SHP-836SHP836
Related Tags: buy SHP836 | purchase SHP836 | SHP836 cost | order SHP836 | SHP836 chemical structure | SHP836 in vitro | SHP836 formula | SHP836 molecular weight
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