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Siplizumab
🥰Excellent
Catalog No. T77170Cas No. 288392-69-8
Alias MEDI-507
Siplizumab (MEDI-507) is a humanized IgG1 monoclonal antibody that targets CD2, selectively depleting effector memory T cells and promoting the relative expansion of alloreactive regulatory T cells in vitro. Siplizumab can be used to treat plaque psoriasis.
Siplizumab
Siplizumab
🥰Excellent
Purity: 100% (SEC-HPLC)
Catalog No. T77170Alias MEDI-507Cas No. 288392-69-8
Siplizumab (MEDI-507) is a humanized IgG1 monoclonal antibody that targets CD2, selectively depleting effector memory T cells and promoting the relative expansion of alloreactive regulatory T cells in vitro. Siplizumab can be used to treat plaque psoriasis.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $222 | In Stock | |
| 5 mg | $647 | In Stock | |
| 10 mg | $987 | In Stock |
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Concentration:12.45 mg/mL
Purity:100% (SEC-HPLC)
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Product Introduction
Bioactivity
Chemical Properties
| Description | Siplizumab (MEDI-507) is a humanized IgG1 monoclonal antibody that targets CD2, selectively depleting effector memory T cells and promoting the relative expansion of alloreactive regulatory T cells in vitro. Siplizumab can be used to treat plaque psoriasis. |
| In vitro | Siplizumab (MEDI-507; 0.00001-10 nM) binds to FcγR, inducing signal transduction, and at concentrations of 0.0001-10 μg/mL, it mediates cell depletion and reduces T-cell proliferation[1]. |
| Alias | MEDI-507 |
| Molecular Weight | 147.24 kDa |
| Cas No. | 288392-69-8 |
Storage & Solubility Information
| Storage | store at low temperature | store at -80°C | Shipping with blue ice. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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