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Siremadlin (R Enantiomer)

Name: Siremadlin (R Enantiomer)
Brand: TargetMol
SKU: T12274
Rating: 4.5 (1 reviews)

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Catalog No. T12274Cas No. 1448867-42-2

Alias Siremadlin R Enantiomer, NVP-HDM201 R Enantiomer, HDM201 R Enantiomer

Siremadlin R Enantiomer is the R enantiomer of Siremadlin. Siremadlin is a potent and highly specific inhibitor of MDM-2/p53.

Siremadlin (R Enantiomer)

😃Good

Catalog No. T12274Alias Siremadlin R Enantiomer, NVP-HDM201 R Enantiomer, HDM201 R EnantiomerCas No. 1448867-42-2

Siremadlin R Enantiomer is the R enantiomer of Siremadlin. Siremadlin is a potent and highly specific inhibitor of MDM-2/p53.

Pack Size	Price	Availability
25 mg	$1,230	8-10 weeks
50 mg	$1,610	8-10 weeks
100 mg	$2,440	8-10 weeks

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Product Introduction

Bioactivity

Description	Siremadlin R Enantiomer is the R enantiomer of Siremadlin. Siremadlin is a potent and highly specific inhibitor of MDM-2/p53.
Alias	Siremadlin R Enantiomer, NVP-HDM201 R Enantiomer, HDM201 R Enantiomer

Chemical Properties

Molecular Weight	555.41
Formula	C₂₆H₂₄Cl₂N₆O₄
Cas No.	1448867-42-2
Relative Density.	1.47 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 56.75 mg/mL (102.18 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.8005 mL	9.0024 mL	18.0047 mL	90.0236 mL
5 mM	0.3601 mL	1.8005 mL	3.6009 mL	18.0047 mL
10 mM	0.1800 mL	0.9002 mL	1.8005 mL	9.0024 mL
20 mM	0.0900 mL	0.4501 mL	0.9002 mL	4.5012 mL
50 mM	0.0360 mL	0.1800 mL	0.3601 mL	1.8005 mL
100 mM	0.0180 mL	0.0900 mL	0.1800 mL	0.9002 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

Siremadlin (R Enantiomer)R EnantiomerSiremadlin