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SIRT2-IN-11

Catalog No. T73000Cas No. 1005095-06-6

SIRT2-IN-11 (AEM1) is a selective inhibitor of SIRT2 with an inhibitory concentration (IC50) of 18.5 μM. It induces apoptosis in a p53-dependent manner, activates the expression of CDKN1A, PUMA, and NOXA, and enhances the acetylation of p53. This compound is utilized in the study of p53-associated cancers.

SIRT2-IN-11

SIRT2-IN-11

Catalog No. T73000Cas No. 1005095-06-6
SIRT2-IN-11 (AEM1) is a selective inhibitor of SIRT2 with an inhibitory concentration (IC50) of 18.5 μM. It induces apoptosis in a p53-dependent manner, activates the expression of CDKN1A, PUMA, and NOXA, and enhances the acetylation of p53. This compound is utilized in the study of p53-associated cancers.
Pack SizePriceAvailabilityQuantity
25 mg$1,0706-8 weeks
50 mg$1,3906-8 weeks
100 mg$2,2306-8 weeks
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Product Introduction

Bioactivity
Description
SIRT2-IN-11 (AEM1) is a selective inhibitor of SIRT2 with an inhibitory concentration (IC50) of 18.5 μM. It induces apoptosis in a p53-dependent manner, activates the expression of CDKN1A, PUMA, and NOXA, and enhances the acetylation of p53. This compound is utilized in the study of p53-associated cancers.
Chemical Properties
Molecular Weight318.41
FormulaC21H22N2O
Cas No.1005095-06-6
Storage & Solubility Information
StorageShipping with blue ice.

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