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SJM-3
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Catalog No. T38621Cas No. 1234977-97-9
SJM-3 is a positive allosteric modulator of various isoforms of the GABAA receptor, binding specifically to the high-affinity benzodiazepine binding site at the α+/γ- subunit interface.
SJM-3
🥰Excellent
Catalog No. T38621Cas No. 1234977-97-9
SJM-3 is a positive allosteric modulator of various isoforms of the GABAA receptor, binding specifically to the high-affinity benzodiazepine binding site at the α+/γ- subunit interface.
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Product Introduction
Bioactivity
Chemical Properties
| Description | SJM-3 is a positive allosteric modulator of various isoforms of the GABAA receptor, binding specifically to the high-affinity benzodiazepine binding site at the α+/γ- subunit interface. |
| In vitro | SJM-3 interacts with the high-affinity benzodiazepine binding site located at the α+/γ- subunit interface, yet it exerts its pharmacological effects via a presumably different site within the transmembrane domain. Its binding affinity at wild type receptors is measured through the displacement of [3H]-Flunitrazepam and [3H]-Ro15-1788, revealing a K i for SJM-3 of 218±70 nM and 242±38 nM, respectively[1]. |
| Molecular Weight | 354.4 |
| Formula | C18H15FN4OS |
| Cas No. | 1234977-97-9 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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