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Description | SJM-3 is a positive allosteric modulator of various isoforms of the GABAA receptor, binding specifically to the high-affinity benzodiazepine binding site at the α+/γ- subunit interface. |
In vitro | SJM-3 interacts with the high-affinity benzodiazepine binding site located at the α+/γ- subunit interface, yet it exerts its pharmacological effects via a presumably different site within the transmembrane domain. Its binding affinity at wild type receptors is measured through the displacement of [3H]-Flunitrazepam and [3H]-Ro15-1788, revealing a K i for SJM-3 of 218±70 nM and 242±38 nM, respectively[1]. |
Molecular Weight | 354.4 |
Formula | C18H15FN4OS |
Cas No. | 1234977-97-9 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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