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SKI-I

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Catalog No. T62022Cas No. 306301-68-8

SKI-I is a potent and selective inhibitor of human sphingosine kinase (SK), with an IC50 of 1.2 μM for ST-hSK, and also inhibits hERK2 (IC50 = 11 μM). SKI-I induces apoptosis in tumor cell lines.

SKI-I

SKI-I

😃Good
Catalog No. T62022Cas No. 306301-68-8
SKI-I is a potent and selective inhibitor of human sphingosine kinase (SK), with an IC50 of 1.2 μM for ST-hSK, and also inhibits hERK2 (IC50 = 11 μM). SKI-I induces apoptosis in tumor cell lines.
Pack SizePriceAvailabilityQuantity
25 mg$9166-8 weeks
50 mg$1,1906-8 weeks
100 mg$1,8606-8 weeks
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Product Introduction

Bioactivity
Description
SKI-I is a potent and selective inhibitor of human sphingosine kinase (SK), with an IC50 of 1.2 μM for ST-hSK, and also inhibits hERK2 (IC50 = 11 μM). SKI-I induces apoptosis in tumor cell lines.
In vitro
SKI-I (Compound I; 5 μg/mL) suppresses SK activity by 99% [1] and, at 10 μM over 24 hours, induces apoptosis in T24 cells [1].
Chemical Properties
Molecular Weight406.44
FormulaC25H18N4O2
Cas No.306301-68-8
Storage & Solubility Information
StorageShipping with blue ice.

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