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SNIPER(ER)-87

SNIPER(ER)-87
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SNIPER(ER)-87

Catalog No. T18697Cas No. 2222354-91-6
SNIPER(ER)-87 is a chemical compound composed of a derivative of the inhibitor of apoptosis protein (IAP) ligand LCL161 conjugated to the estrogen receptor α (ERα) ligand 4-hydroxytamoxifen using a PEG linker. It effectively degrades the ERα protein with an IC50 value of 0.097 μM. Within cells, SNIPER(ER)-87 selectively recruits XIAP to ERα, and XIAP functions as the primary E3 ubiquitin ligase responsible for the degradation of ERα induced by SNIPER(ER)-87[1][2].
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Product Introduction

Bioactivity
Description
SNIPER(ER)-87 is a chemical compound composed of a derivative of the inhibitor of apoptosis protein (IAP) ligand LCL161 conjugated to the estrogen receptor α (ERα) ligand 4-hydroxytamoxifen using a PEG linker. It effectively degrades the ERα protein with an IC50 value of 0.097 μM. Within cells, SNIPER(ER)-87 selectively recruits XIAP to ERα, and XIAP functions as the primary E3 ubiquitin ligase responsible for the degradation of ERα induced by SNIPER(ER)-87[1][2].
In vitro
SNIPER(ER)-87, at concentrations ranging from 0.1 to 1000 nM over 72 hours, effectively suppresses ERα-dependent transcriptional activation induced by β-estradiol and inhibits the proliferation of ERα-positive breast cancer cells, achieving IC50 values of 15.6 nM in MCF-7 cells and 9.6 nM in T47D cells[1].
In vivo
SNIPER(ER)-87, administered intraperitoneally at a dosage of 30 mg/kg every 24 hours for a duration of 14 days, effectively suppresses the development of MCF-7 orthotopic breast tumor xenografts in six-week-old female BALB/c nude mice[1].
Chemical Properties
Molecular Weight1044.32
FormulaC59H73N5O10S
Cas No.2222354-91-6
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year

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Mother liquor preparation method: 2 mg of drug dissolved in 50 μLDMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μLDMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μLTween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify.
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