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SNIPER(ER)-87

Catalog No. T18697Cas No. 2222354-91-6

SNIPER(ER)-87 is a chemical compound composed of a derivative of the inhibitor of apoptosis protein (IAP) ligand LCL161 conjugated to the estrogen receptor α (ERα) ligand 4-hydroxytamoxifen using a PEG linker. It effectively degrades the ERα protein with an IC50 value of 0.097 μM. Within cells, SNIPER(ER)-87 selectively recruits XIAP to ERα, and XIAP functions as the primary E3 ubiquitin ligase responsible for the degradation of ERα induced by SNIPER(ER)-87[1][2].

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Pack Size	Price	Availability	Quantity
5 mg	$1,980	Backorder

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Product Introduction

Bioactivity

Description	SNIPER(ER)-87 is a chemical compound composed of a derivative of the inhibitor of apoptosis protein (IAP) ligand LCL161 conjugated to the estrogen receptor α (ERα) ligand 4-hydroxytamoxifen using a PEG linker. It effectively degrades the ERα protein with an IC50 value of 0.097 μM. Within cells, SNIPER(ER)-87 selectively recruits XIAP to ERα, and XIAP functions as the primary E3 ubiquitin ligase responsible for the degradation of ERα induced by SNIPER(ER)-87[1][2].
In vitro	SNIPER(ER)-87, at concentrations ranging from 0.1 to 1000 nM over 72 hours, effectively suppresses ERα-dependent transcriptional activation induced by β-estradiol and inhibits the proliferation of ERα-positive breast cancer cells, achieving IC50 values of 15.6 nM in MCF-7 cells and 9.6 nM in T47D cells[1].
In vivo	SNIPER(ER)-87, administered intraperitoneally at a dosage of 30 mg/kg every 24 hours for a duration of 14 days, effectively suppresses the development of MCF-7 orthotopic breast tumor xenografts in six-week-old female BALB/c nude mice[1].

Chemical Properties

Molecular Weight	1044.32
Formula	C59H73N5O10S
Cas No.	2222354-91-6

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

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A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

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