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SNT-207707

Name: SNT-207707
Brand: TargetMol
SKU: T12944
Rating: 4.5 (1 reviews)

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Catalog No. T12944Cas No. 1064662-40-3

SNT-207707 is a potent, selective and orally active antagonist of melanocortin MC-4 receptor(IC50 of 8 nM (binding) and 5 nM (function) on the MC-4 receptor).

SNT-207707

😃Good

Catalog No. T12944Cas No. 1064662-40-3

SNT-207707 is a potent, selective and orally active antagonist of melanocortin MC-4 receptor(IC50 of 8 nM (binding) and 5 nM (function) on the MC-4 receptor).

Pack Size	Price	Availability
25 mg	$1,520	6-8 weeks
50 mg	$1,980	6-8 weeks
100 mg	$2,500	6-8 weeks

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Product Introduction

Bioactivity

Description	SNT-207707 is a potent, selective and orally active antagonist of melanocortin MC-4 receptor(IC50 of 8 nM (binding) and 5 nM (function) on the MC-4 receptor).
Targets&IC50	MC-4 (binding):8 nM , MC-4 (function):5 nM
In vitro	SNT-207707 binds to MC-4 receptor with an affinity of 8 nM, and has over 200-fold selectivity vs. MC-3 and MC-5. SNT207858 is a 22 nM MC-4 antagonist with a 170-fold selectivity vs. MC-3 and a 40-fold selectivity versus MC-5.
In vivo	food intake of the mice distinctly increased by SNT-207707(Single subcutaneous injection of 20 mg/kg). Once daily oral administration of both compounds SNT207858 and SNT-207707 starting the day after tumor implantation significantly reduces the tumor induced weight loss.

Chemical Properties

Molecular Weight	550.18
Formula	C₃₂H₄₄ClN₅O
Cas No.	1064662-40-3
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 250 mg/mL (454.40 mM)

MEthanol: 250 mg/mL (454.40 mM), Sonication is recommended.

Solution Preparation Table

DMSO/MEthanol

	1mg	5mg	10mg	50mg
1 mM	1.8176 mL	9.0879 mL	18.1759 mL	90.8793 mL
5 mM	0.3635 mL	1.8176 mL	3.6352 mL	18.1759 mL
10 mM	0.1818 mL	0.9088 mL	1.8176 mL	9.0879 mL
20 mM	0.0909 mL	0.4544 mL	0.9088 mL	4.5440 mL
50 mM	0.0364 mL	0.1818 mL	0.3635 mL	1.8176 mL
100 mM	0.0182 mL	0.0909 mL	0.1818 mL	0.9088 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

SNT-207707SNT207707SNT 207707function MC-4binding MC-4