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Description | Sodium zirconium cyclosilicate, an orally administered, non-absorbed, microporous zirconium silicate, acts as a highly selective cation exchanger to remove excess potassium (K+) in vivo. It has potential use in the research of chronic kidney disease (CKD) [1] [2]. |
In vitro | Sodium zirconium cyclosilicate (ZS-9) is a crystalline, inorganic cation exchanger highly selective for trapping excess monovalent cations, particularly K+ and ammonium ions. Its exchange capacity for divalent ions such as Ca2+ and Mg2+ is less than 0.05 mEq/g, with over 25-fold greater selectivity for K+ than for Ca2+ or Mg2+ [1]. |
In vivo | Sodium zirconium cyclosilicate (ZS-9; 2-6 g/kg; p.o.; daily, for 5 days) effectively uptakes and removes potassium ions in Sprague-Dawley rats, with subsequent recovery in feces [2]. |
Molecular Weight | 365.46 |
Formula | Na2O9Si3Zr |
Cas No. | 17141-74-1 |
Storage | store at low temperature Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
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