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Pack Size | Price | Availability | Quantity |
---|---|---|---|
25 mg | $1,670 | 6-8 weeks | |
50 mg | $2,180 | 6-8 weeks | |
100 mg | $2,800 | 6-8 weeks |
Description | Sofiniclin (ABT 894) is an agonist of nicotinic acetylcholine receptor (nAChR). It is used for the research for attention-deficit/hyperactivity disorder (ADHD). |
In vitro | Sofiniclin is more potent than ABT-089 at both receptor subtypes, with Ki values of 1.3 nM for 125I-epibatidine binding and of 1.9 nM for 125I-α-conotoxinMII binding [1]. |
In vivo | In a comparative study with a vehicle control, Sofiniclin (administered orally at doses ranging from 0.001 to 0.10 mg/kg) significantly decreases Levodopa-Induced Dyskinesia (LIDs) [1]. However, at a dose of 0.1 mg/kg, Sofiniclin does not reduce LIDs in monkeys exhibiting severe nigrostriatal damage [2]. |
Alias | ABT 894 |
Molecular Weight | 244.12 |
Formula | C10H11Cl2N3 |
Cas No. | 799279-80-4 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
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