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Sofnobrutinib
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Catalog No. T72865Cas No. 1646608-10-7
Alias AS-0871
Sofnobrutinib (AS-0871) is an orally active, selective inhibitor of Bruton's tyrosine kinase (BTK) with IC50 values of 4.2 nM for activated BTK and 0.39 nM for unactivated BTK. It has an IC50 of 24 μM against hERG, exhibits strong metabolic stability and bioavailability, induces a weak passive cutaneous anaphylaxis reaction, and demonstrates anti-inflammatory properties in a mouse model of collagen-induced arthritis.
Sofnobrutinib
😃Good
Catalog No. T72865Alias AS-0871Cas No. 1646608-10-7
Sofnobrutinib (AS-0871) is an orally active, selective inhibitor of Bruton's tyrosine kinase (BTK) with IC50 values of 4.2 nM for activated BTK and 0.39 nM for unactivated BTK. It has an IC50 of 24 μM against hERG, exhibits strong metabolic stability and bioavailability, induces a weak passive cutaneous anaphylaxis reaction, and demonstrates anti-inflammatory properties in a mouse model of collagen-induced arthritis.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 25 mg | $1,970 | 8-10 weeks | |
| 50 mg | $2,580 | 8-10 weeks | |
| 100 mg | $3,400 | 8-10 weeks |
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Product Introduction
Bioactivity
Chemical Properties
| Description | Sofnobrutinib (AS-0871) is an orally active, selective inhibitor of Bruton's tyrosine kinase (BTK) with IC50 values of 4.2 nM for activated BTK and 0.39 nM for unactivated BTK. It has an IC50 of 24 μM against hERG, exhibits strong metabolic stability and bioavailability, induces a weak passive cutaneous anaphylaxis reaction, and demonstrates anti-inflammatory properties in a mouse model of collagen-induced arthritis. |
| Alias | AS-0871 |
| Molecular Weight | 498.51 |
| Formula | C26H23FN8O2 |
| Cas No. | 1646608-10-7 |
Storage & Solubility Information
| Storage | Shipping with blue ice. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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