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Sograzepide

Name: Sograzepide
Brand: TargetMol
SKU: T16906
Price: 84 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T16906Cas No. 155488-25-8

Alias YM-220, YM220, YF476, YF 476, Netazepide

Sograzepide (Netazepide) is an orally active, selective and highly potent gastrin/CCK-B antagonist that inhibits gastrin/CCK-A activity and pappalysin 2 expression in type 1 gastric neuroendocrine tumors, and can induce regression of type 1 gastric neuroendocrine tumors.

Sograzepide

🥰Excellent

Catalog No. T16906Alias YM-220, YM220, YF476, YF 476, NetazepideCas No. 155488-25-8

Pack Size	Price	Availability	Quantity
1 mg	$84	In Stock
5 mg	$358	In Stock

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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Product Introduction

Bioactivity

Description	Sograzepide (Netazepide) is an orally active, selective and highly potent gastrin/CCK-B antagonist that inhibits gastrin/CCK-A activity and pappalysin 2 expression in type 1 gastric neuroendocrine tumors, and can induce regression of type 1 gastric neuroendocrine tumors.
Targets&IC50	Gastrin/CCK-A:501 nM, Gastrin/CCK-B:0.1 nM
In vivo	Intravenous Sograzepide (0.1 μmol/kg) inhibited gastrin-induced gastric acid secretion in anesthetized rats at a dose of ED50 = 87 nM/kg. [1] At a dose of 10 μM/kg, Sograzepide showed inhibition of gastrin-induced gastric acid secretion with an ED50 = 0.0086 μM/kg, but had no effect on histamine- and bethanechol-induced gastric acid secretion. [2]
Alias	YM-220, YM220, YF476, YF 476, Netazepide

Chemical Properties

Molecular Weight	498.58
Formula	C₂₈H₃₀N₆O₃
Cas No.	155488-25-8
Smiles	C(C(C(C)(C)C)=O)N1C=2C(C(=N[C@@H](NC(NC3=CC(NC)=CC=C3)=O)C1=O)C4=CC=CC=N4)=CC=CC2
Relative Density.	1.25 g/cm3

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 80 mg/mL(160.46 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0057 mL	10.0285 mL	20.0570 mL	100.2848 mL
5 mM	0.4011 mL	2.0057 mL	4.0114 mL	20.0570 mL
10 mM	0.2006 mL	1.0028 mL	2.0057 mL	10.0285 mL
20 mM	0.1003 mL	0.5014 mL	1.0028 mL	5.0142 mL
50 mM	0.0401 mL	0.2006 mL	0.4011 mL	2.0057 mL
100 mM	0.0201 mL	0.1003 mL	0.2006 mL	1.0028 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

YM 220YF-476SograzepideGastrin/CCK-BGastrin/CCK-AGastrin