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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $170 | 35 days | |
5 mg | $755 | 35 days |
Description | Sp-cAMPS sodium salt is an analog of cAMP that is a potent activator of cAMP-dependent PKA I and PKA II. Sp-cAMPS sodium salt is also a potent, competitive phosphodiesterase (PDE3A) inhibitor with a K i of 47.6 μM. Sp-cAMPS sodium salt binds the PDE10 GAF domain with an EC 50 of 40 μM [1] [2] [3]. |
In vitro | The glucagon-stimulated increases in the level of Ca 2+ can be mimicked by Sp-cAMPS. Treatment of hepatocytes with Sp-cAMPS which is the stimulatory diastereomer of adenosine cyclic 3',5'-phosphorothioate, mimics the response seen with glucagon [4]. |
In vivo | In chronic alcohol consumption (CAC) mice, direct infusion of the PKA activator (Sp-cAMPS) (1 μg/μL) into the prefrontal cortex significantly improves or impairs, respectively, working memory performance in withdrawn and water animals [5]. |
Molecular Weight | 367.25 |
Formula | C10H12N5NaO5PS+ |
Cas No. | 142439-95-0 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
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