Powder: -20°C for 3 years | In solvent: -80°C for 1 year
SR 12460 is a mimetic of the IκB kinase β (IKKβ) NEMO/IKKγ-binding domain (NBD) that inhibits the protein-protein interaction between the IKK complex subunits NF-κB essential modulator (NEMO/IKKγ) and IKKβ.1It inhibits TNF-α-induced NF-κB activation in a reporter assay when used at concentrations ranging from 25 to 150 μM. It reduces LPS-induced production of IL-6 in RAW 264.7 cells. SR 12460 (30 mg/kg) improves grip strength in themdxmouse model of Duchenne muscular dystrophy.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | 35 days | $ 95.00 | |
5 mg | 35 days | $ 278.00 | |
10 mg | 35 days | $ 492.00 | |
25 mg | 35 days | $ 1,140.00 |
Description | SR 12460 is a mimetic of the IκB kinase β (IKKβ) NEMO/IKKγ-binding domain (NBD) that inhibits the protein-protein interaction between the IKK complex subunits NF-κB essential modulator (NEMO/IKKγ) and IKKβ.1It inhibits TNF-α-induced NF-κB activation in a reporter assay when used at concentrations ranging from 25 to 150 μM. It reduces LPS-induced production of IL-6 in RAW 264.7 cells. SR 12460 (30 mg/kg) improves grip strength in themdxmouse model of Duchenne muscular dystrophy. |
Molecular Weight | 325.74 |
Formula | C15H14ClF2N3O |
CAS No. | 2055101-66-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMF: 30 mg/mL
DMSO: 15 mg/mL
You can also refer to dose conversion for different animals. More
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SR 12460 2055101-66-9 SR12460 SR-12460 inhibitor inhibit