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SR 12460

Name: SR 12460
Brand: TargetMol
SKU: T37449
Rating: 4.5 (1 reviews)

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Catalog No. T37449Cas No. 2055101-66-9

Alias SR12460

SR 12460 is a lead NBD mimic, inhibiting the interaction between IKKβ and NEMO, suppressing TNF-α and LPS-induced NF-κB activation, and reducing LPS-induced acute pulmonary inflammation in mice.

SR 12460

😃Good

Catalog No. T37449Alias SR12460Cas No. 2055101-66-9

SR 12460 is a lead NBD mimic, inhibiting the interaction between IKKβ and NEMO, suppressing TNF-α and LPS-induced NF-κB activation, and reducing LPS-induced acute pulmonary inflammation in mice.

Pack Size	Price	Availability
1 mg	$139	35 days
5 mg	$369	In Stock
10 mg	$669	35 days
25 mg	$1,518	35 days

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COA

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Product Introduction

Bioactivity

Description	SR 12460 is a lead NBD mimic, inhibiting the interaction between IKKβ and NEMO, suppressing TNF-α and LPS-induced NF-κB activation, and reducing LPS-induced acute pulmonary inflammation in mice.
In vitro	SR 12460 inhibited TNF-α-mediated NF-κB activation with a maximum median inhibitory concentration (IC50) of 11.34 μM. SR 12460 (50 μM) inhibits tumor necrosis factor α (TNF-α) and lipopolysaccharide (LPS) -induced NF-κB activation by blocking the interaction between IKKβ and NEMO. [1]
In vivo	SR 12460 (10 mg/kg, intraperitoneal injection) inhibited LPS-induced acute lung inflammation in mice. SR 12460 (30 mg/kg intraperitoneally administered) significantly improved muscle function and muscle pathology in mdx mice. [1]
Alias	SR12460

Chemical Properties

Molecular Weight	325.74
Formula	C₁₅H₁₄ClF₂N₃O
Cas No.	2055101-66-9
Smiles	O=C(NC1=NC=C(Cl)C=C1)CNCCC=2C=C(F)C=C(F)C2

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMF: 8 mg/mL (24.56 mM), Sonication is recommended.

DMSO: 8 mg/mL (24.56 mM), Sonication is recommended.

Solution Preparation Table

DMF/DMSO

	1mg	5mg	10mg	50mg
1 mM	3.0699 mL	15.3497 mL	30.6993 mL	153.4967 mL
5 mM	0.6140 mL	3.0699 mL	6.1399 mL	30.6993 mL
10 mM	0.3070 mL	1.5350 mL	3.0699 mL	15.3497 mL
20 mM	0.1535 mL	0.7675 mL	1.5350 mL	7.6748 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

SR-12460SR 12460