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SRX246
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Catalog No. T16934Cas No. 512784-93-9
SRX246 has no interaction at V1b and V2 receptors. SRX246 shows negligible binding at 64 other receptors classes, including 35 G-proteincoupled receptors. SRX246 is a potent and CNS-penetrant vasopressin 1a (V1a) receptor antagonist (Ki=0.3 nM for human V1a).
SRX246
😃Good
Catalog No. T16934Cas No. 512784-93-9
SRX246 has no interaction at V1b and V2 receptors. SRX246 shows negligible binding at 64 other receptors classes, including 35 G-proteincoupled receptors. SRX246 is a potent and CNS-penetrant vasopressin 1a (V1a) receptor antagonist (Ki=0.3 nM for human V1a).
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 25 mg | $987 | 8-10 weeks | |
| 50 mg | $1,360 | 8-10 weeks | |
| 100 mg | $1,860 | 8-10 weeks |
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Product Introduction
Bioactivity
Chemical Properties
| Description | SRX246 has no interaction at V1b and V2 receptors. SRX246 shows negligible binding at 64 other receptors classes, including 35 G-proteincoupled receptors. SRX246 is a potent and CNS-penetrant vasopressin 1a (V1a) receptor antagonist (Ki=0.3 nM for human V |
| Targets&IC50 | V1a receptor (human):（ki）0.3 nM |
| In vivo | SRX246 (2 mg/kg; i.v.) treatment results in plasma pharmacokinetic values of Cmax 953 ng/mL, AUC0-∞ 1141 ng∙h/mL, and t1/2 6.02 hours. SRX246 (20 mg/kg; p.o.) administration yields Cmax 98.4 ng/mL, AUC0-∞ 624 ng∙h/mL, and t1/2 2.38 hours, respectively [1]. |
| Molecular Weight | 703.87 |
| Formula | C42H49N5O5 |
| Cas No. | 512784-93-9 |
| Relative Density. | 1.281 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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