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ST 2825

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Catalog No. T16937Cas No. 894787-30-5

ST 2825 is a specific MyD88 dimerization inhibitor that blocks IL-1β-mediated activation of NF-κB transcriptional activity.

ST 2825

ST 2825

😃Good
Catalog No. T16937Cas No. 894787-30-5
ST 2825 is a specific MyD88 dimerization inhibitor that blocks IL-1β-mediated activation of NF-κB transcriptional activity.
Pack SizePriceAvailabilityQuantity
25 mg$1,970 8-10 weeks
50 mg$2,580 8-10 weeks
100 mg$3,400 8-10 weeks
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Product Introduction

Bioactivity
Description
ST 2825 is a specific MyD88 dimerization inhibitor that blocks IL-1β-mediated activation of NF-κB transcriptional activity.
In vitro
ST2825 inhibits IL-1R/TLR signaling by disrupting MyD88 homodimerization in a concentration-dependent manner, achieving approximately 40% inhibition at 5 μM and 80% inhibition at 10 μM ST2825 [1].
In vivo
ST2825 effectively reduces IL-1β-induced IL-6 production in mice through oral administration, showing significant inhibition at 100 and 200 mg/kg doses. Mice receive oral doses of ST2825 or vehicles, ranging from 50 to 200 mg/kg, five minutes before intraperitoneal (i.p.) injections of 20 μg/kg IL-1β [1].
Chemical Properties
Molecular Weight591.51
FormulaC27H28Cl2N4O5S
Cas No.894787-30-5
Relative Density.1.51 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 100 mg/mL (169.06 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.6906 mL8.4529 mL16.9059 mL84.5294 mL
5 mM0.3381 mL1.6906 mL3.3812 mL16.9059 mL
10 mM0.1691 mL0.8453 mL1.6906 mL8.4529 mL
20 mM0.0845 mL0.4226 mL0.8453 mL4.2265 mL
50 mM0.0338 mL0.1691 mL0.3381 mL1.6906 mL
100 mM0.0169 mL0.0845 mL0.1691 mL0.8453 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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