Steroid sulfatase/17β-HSD1-IN-1

Name: Steroid sulfatase/17β-HSD1-IN-1
Brand: TargetMol
SKU: T61716
Price: 228 USD
Availability: InStock
Rating: 4.5 (1 reviews)

Steroid sulfatase/17β-HSD1-IN-1 is a highly effective inhibitor of steroid sulfatase and 17β-hydroxysteroid dehydrogenase type 1 (17β-HSD1) activities, with an IC50 value of 28 nM against cellular human steroid sulfatase. This compound holds significant potential for investigating estrogen-dependent diseases [1].

Catalog No. T61716

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Steroid sulfatase/17β-HSD1-IN-1

Catalog No. T61716

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Pack Size	Price	Availability
25 mg	$1,520	10-14 weeks
50 mg	$1,980	10-14 weeks
100 mg	$2,500	10-14 weeks

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Product Introduction

Bioactivity

Description	Steroid sulfatase/17β-HSD1-IN-1 is a highly effective inhibitor of steroid sulfatase and 17β-hydroxysteroid dehydrogenase type 1 (17β-HSD1) activities, with an IC50 value of 28 nM against cellular human steroid sulfatase. This compound holds significant potential for investigating estrogen-dependent diseases [1].
In vitro	Steroid sulfatase/17β-HSD1-IN-1 (compound 13) exhibits low cytotoxicity, inhibiting HEK-293 cell growth by 12.8% at 20 μM for 48 hours. In T47D cells, it effectively inhibits cell growth and 17β-HSD1 activity in a time-dependent manner at concentrations of 50 to 750 nM over 0 to 25 minutes.
In vivo	Steroid sulfatase/17β-HSD1-IN-1 shows high metabolic stability in the human hepatic S9 fraction, with a half-life (t1/2) of 47 minutes and low intrinsic clearance (Clint) at 15 μL/min/mg protein [1].

Chemical Properties

Molecular Weight	386.42
Formula	C₁₉H₁₈N₂O₅S

Storage & Solubility Information

Storage

Shipping with blue ice.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

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