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STING agonist-3

Name: STING agonist-3
Brand: TargetMol
SKU: T13014
Rating: 4.5 (1 reviews)

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Catalog No. T13014Cas No. 2138299-29-1

STING agonist-3 is a selective and non-nucleotide small-molecule STING agonist(pEC50 and pIC50 of 7.5 and 9.5, respectively), has durable anti-tumor effect and tremendous potential to improve treatment of cancer.

STING agonist-3

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Catalog No. T13014Cas No. 2138299-29-1

Pack Size	Price	Availability
500 μg	$155	35 days
1 mg	$288	35 days
5 mg	$1,190	35 days
10 mg	$1,980	35 days

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Product Introduction

Bioactivity

Description

In vitro

STING agonist-3 exhibits activation of STING in cells(pEC50 of 7.5), this assay is determined using a luciferase reporter assay in human embryonic kidney cells (HEK293T) co-transfected with plasmids expressing STING and the enzyme firefly luciferase driven by the interferon stimulated response element promoter.In FRET assay, STING agonist-3 exhibits a pIC50 value of 9.5 . This is a competition binding assay which aims to determine the binding potency of molecules to the C-terminal Domain (CTD) of human STING.

Chemical Properties

Molecular Weight	750.81
Formula	C₃₇H₄₂N₁₂O₆
Cas No.	2138299-29-1
Relative Density.	1.47 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 125 mg/mL (166.49 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.3319 mL	6.6595 mL	13.3189 mL	66.5947 mL
5 mM	0.2664 mL	1.3319 mL	2.6638 mL	13.3189 mL
10 mM	0.1332 mL	0.6659 mL	1.3319 mL	6.6595 mL
20 mM	0.0666 mL	0.3330 mL	0.6659 mL	3.3297 mL
50 mM	0.0266 mL	0.1332 mL	0.2664 mL	1.3319 mL
100 mM	0.0133 mL	0.0666 mL	0.1332 mL	0.6659 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

STING agonist-3STING agonist3STING agonist 3