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STL1267

Name: STL1267
Brand: TargetMol
SKU: T73443
Price: 56 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T73443Cas No. 1429024-58-7

Alias STL 1267

STL1267 is a REV-ERB agonist that can cross the blood-brain barrier and inhibits BMAL1 gene expression. It can be used to study chronic diseases and inflammatory pain.

STL1267

🥰Excellent

Catalog No. T73443Alias STL 1267Cas No. 1429024-58-7

STL1267 is a REV-ERB agonist that can cross the blood-brain barrier and inhibits BMAL1 gene expression. It can be used to study chronic diseases and inflammatory pain.

Pack Size	Price	Availability
2 mg	$56	In Stock
5 mg	$89	In Stock
10 mg	$139	In Stock
25 mg	$289	In Stock
50 mg	$479	In Stock
100 mg	$762	In Stock
1 mL x 10 mM (in DMSO)	$98	In Stock

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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Product Introduction

Bioactivity

Description	STL1267 is a REV-ERB agonist that can cross the blood-brain barrier and inhibits BMAL1 gene expression. It can be used to study chronic diseases and inflammatory pain.
Targets&IC50	REV-ERBα:0.16 µM (Ki)
In vitro	STL1267 is an agonist of REV-ERB with a Ki value of 0.16 µM for Rev-erbα. The EC50 collected by STL1267 for NCoR ID1 is 0.13μM. [1]
In vivo	Intraperitoneal injection of STL1267 (50 mg/kg) into C57Bl / 6 J mice showed that STL1267 successfully crossed the blood-brain barrier with a plasma half-life of ~1.6 hours. [1]
Alias	STL 1267

Chemical Properties

Molecular Weight	322.75
Formula	C₁₇H₁₁ClN₄O
Cas No.	1429024-58-7
Smiles	ClC1=NN=C2C=CC(=NN12)OC=3C=CC=CC3C=4C=CC=CC4

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 20 mg/mL (61.97 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.0984 mL	15.4919 mL	30.9837 mL	154.9187 mL
5 mM	0.6197 mL	3.0984 mL	6.1967 mL	30.9837 mL
10 mM	0.3098 mL	1.5492 mL	3.0984 mL	15.4919 mL
20 mM	0.1549 mL	0.7746 mL	1.5492 mL	7.7459 mL
50 mM	0.0620 mL	0.3098 mL	0.6197 mL	3.0984 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc