Streptokinase is a bacterial protein that acts as a plasminogen activator, commonly employed in the investigation of blood-clotting disorders. Its application extends to enhancing reperfusion blood flow after coronary artery occlusion.

Streptokinase, administered intracoronarily at a dosage of 6000 IU/kg in 3 ml of saline and infused at a rate of 0.05 ml/min for 60 minutes starting 30 minutes prior to reperfusion, effectively sustains coronary blood flow through significant stenosis at rates comparable to baseline levels[2].