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Pack Size | Price | Availability | Quantity |
---|---|---|---|
500 μg | $65 | 35 days | |
1 mg | $98 | 35 days | |
5 mg | $320 | 35 days | |
10 mg | $497 | 35 days |
Description | Sulfonadyn-47 is a dynamin inhibitor that effectively inhibits dynamin GTPase activity with an IC50 of 3.5 µM in cell-free assays. Additionally, it disrupts clathrin-mediated endocytosis in U2OS cells (IC50 = 27.3 µM) and impedes the depolarization-stimulated uptake of the synaptic vesicle endocytosis (SVE) marker FM4-64 in isolated rat brain synaptosomes (IC50 = 12.3 µM). Significantly, in vivo administration of sulfonadyn-47 at doses of 30 and 60 mg/kg demonstrates anticonvulsant properties in the 6 Hz corneal kindling mouse model of seizures. |
Molecular Weight | 459.40 |
Formula | C22H23BrN2O2S |
Cas No. |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
Solubility Information | DMF: 10 mg/ml DMSO: 10 mg/ml |
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