Shopping Cart
- Remove All
Your shopping cart is currently empty
SUN B8155
🥰Excellent
Catalog No. T23406Cas No. 345893-91-6
Alias SUN-B 8155
SUN B8155 is a calcitonin (CT) receptor agonist that selectively mimics the biological effects of calcitonin and induces cAMP formation in cells expressing recombinant human CT receptor.
SUN B8155
🥰Excellent
Purity: 99.38%
Catalog No. T23406Alias SUN-B 8155Cas No. 345893-91-6
SUN B8155 is a calcitonin (CT) receptor agonist that selectively mimics the biological effects of calcitonin and induces cAMP formation in cells expressing recombinant human CT receptor.
Product information is being updated, if you want to purchase, please click the bulk custom button.
Bulk & Custom
Questions
View MoreInhibitors Related to "SUN B8155"
Rimegepant
Cited
BMS-927711, BMS927711, BMS 927711, BHV-3000
T46101289023-67-1
Rimegepant (BMS 927711) is a highly potent, oral calcitonin gene-related peptide (CGRP) receptor antagonist with a Ki value of 0.027 nM.
- $50
Size
QTY
CitedAtogepant
MK8031. Atogepant, MK-8031, MK 8031, AGN-241689, AGN241689
T266821374248-81-3
Atogepant (MK-8031) is an orally available, selective and potent calcitonin gene-related peptide receptor (CGRP) antagonist for the study of migraine.
- $169
Size
QTY
HCGRP-(8-37) acetate
HCGRP-(8-37) acetate (119911-68-1 free base)
TP1134L
HCGRP-(8-37) acetate is a human calcitonin gene-related peptide (hCGRP) fragment acetate and also an antagonist of CGRP receptor.
- $172
Size
QTY
β-CGRP, human acetate
β-CGRP, human acetate (101462-82-2 free), Human β-CGRP acetate, CGRP-II (Human) (acetate)
TP2167
β-CGRP, human acetate is one of calcitonin peptides and acts via the complex of receptor-activity-modifying protein (RAMP) and calcitonin-receptor-like receptor (CRLR) (IC50s: 1 nM and 300 nM for CRLR/RAMP1 and CRLR/RAMP2 in cells).
- $382
Size
QTY
Calcitonin（salmon） Acetate(47931-85-1(free base))
Salmon calcitonin
TP1040L
Calcitonin(salmon)Acetate(47931-85-1(free base))(Salmon calcitonin) , a calcium regulating hormone, is used to treat osteoporosis in women who are at least 5 years past menopause.
- $96
Size
QTY
Vazegepant hydrochloride
Vazegepant HCl
T86821414976-20-7
Vazegepant hydrochloride (Vazegepant HCl) is the first intranasal gepant for the acute treatment of migraine and has announced a positive phase II/III study.
- $109
Size
QTY
Ubrogepant
MK-1602
T171941374248-77-7
Ubrogepant (MK-1602) is a calcitonin gene-related peptide receptor antagonist used in acute migraine treatment studies.
- $155
Size
QTY
CGRP antagonist 1
T134531123757-49-2In house
CGRP antagonist 1 is a potent CGRP receptor antagonist with Ki values of 35 nM and IC50 values of 57 nM, respectively.CGRP antagonist 1 can be used for the study of cardiovascular and neurovascular diseases.
- $342
Size
QTY
Galcanezumab
LY 2951742
T766821578199-75-3
Galcanezumab is a humanized IgG4 monoclonal antibody targeting the CGRP ligand, which binds to the ligand calcitonin gene-related peptide. Galcanezumab can be used to prevent and treat migraines or cluster headaches.
- $129
Size
QTY
Calcitonin (salmon)
Salmon calcitonin, Calcitonin salmon
TP104047931-85-1
Calcitonin (salmon), a calcium regulating hormone, is used to treat osteoporosis in women who are at least 5 years past menopause.
- $98
Size
QTY
Vazegepant
Zavegepant, BMS-742413, BHV-3500
T387341337918-83-8
Vazegepant (Zavegepant) is an orally available and selective antagonist of the calcitonin gene-related peptide CGRP receptor for pain relief and may be used in the study of migraine.
- $106
Size
QTY
Olcegepant
BIBN-4096, BIBN 4096BS
T12293L204697-65-4
Olcegepant (BIBN-4096) is an effective and selective non-peptide calcitonin gene-related peptide 1 (CGRP1) receptor antagonist (IC50 of 0.03 nM and Ki of 14.4 pM for human CGRP).
- $31
Size
QTY
Select Batch
Purity:99.38%
Contact us for more batch information
Resource Download
Product Introduction
Bioactivity
Chemical Properties
| Description | SUN B8155 is a calcitonin (CT) receptor agonist that selectively mimics the biological effects of calcitonin and induces cAMP formation in cells expressing recombinant human CT receptor. |
| Targets&IC50 | cAMP:21 μM (EC50) |
| In vitro | SUN B8155 (1-1000 μM, 1 hr treatment) promoted intracellular cAMP production in a concentration-dependent manner in T47D cells, with cAMP levels increasing approximately 42-fold at the highest concentration. The compound also increased cAMP production in the UMR106-06 cell line derived from rat osteogenic sarcoma. In CHO/hPTHR or CHO parental cells, SUN B8155 was unable to trigger cAMP production. However, in CHO/hCTR cells, SUN B8155 significantly enhanced cAMP generation in a concentration-dependent manner with an EC50 of 21 μM. [1] |
| In vivo | Intraperitoneal injection of SUN B8155 (100 mg/kg) resulted in a significant decrease in serum calcium concentration of approximately 9% at 30 minutes post-dose.[1] |
| Alias | SUN-B 8155 |
| Molecular Weight | 273.29 |
| Formula | C14H15N3O3 |
| Cas No. | 345893-91-6 |
| Smiles | O=C1C=C(C(=C(O)N1O)C(=NC=2C=CC=CC2N)C)C |
| Relative Density. | 1.34 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 80 mg/mL (292.73 mM), Sonication is recommended | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
| ||||||||||||||||||||||||||||||||||||
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Preview
Related Tags: buy SUN B8155 | purchase SUN B8155 | SUN B8155 cost | order SUN B8155 | SUN B8155 chemical structure | SUN B8155 in vivo | SUN B8155 in vitro | SUN B8155 formula | SUN B8155 molecular weight
- TOP
Feedback
Hello! How can I help you today? 
Copyright © 2015-2024 TargetMol Chemicals Inc. All Rights Reserved.