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A-893
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Catalog No. T5381Cas No. 1868232-32-9
A-893 is a cell-active inhibitor of Methyltransferase SMYD2 (IC50 = 2.8 nM).
A-893
😃Good
Catalog No. T5381Cas No. 1868232-32-9
A-893 is a cell-active inhibitor of Methyltransferase SMYD2 (IC50 = 2.8 nM).
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 25 mg | $1,520 | 10-14 weeks | |
| 50 mg | $1,980 | 10-14 weeks | |
| 100 mg | $2,500 | 10-14 weeks |
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Product Introduction
Bioactivity
Chemical Properties
| Description | A-893 is a cell-active inhibitor of Methyltransferase SMYD2 (IC50 = 2.8 nM). |
| In vitro | Treatment with A-893 or AZ505 leads to a decrease in the ratio of p53K370me1 to total p53 levels, with AZ505 prompting a more significant response. Despite A-893 not affecting overall p53 levels, AZ505 results in an unexpected increase of over threefold. Further analysis indicates that A-893 reduces the p53K370me1 methyl mark by 42%, whereas AZ505 achieves a 28% reduction, slightly less effectively [1]. |
| Molecular Weight | 577.54 |
| Formula | C29H38Cl2N4O4 |
| Cas No. | 1868232-32-9 |
| Relative Density. | 1.32 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
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Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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