t 26c

T-26c is a highly potent and selective matrix metalloproteinase-13 (MMP-13) inhibitor with an IC50 of 6.75 pM.

Highly potent and selective MMP13 inhibitor (IC50 = 6.9 pM). Exhibits >2600-fold selectivity for MMP13 over related MMPs. Inhibits degradation of bovine nasal septum cartilage explants in vitro . Orally bioavailable. Nara et al (2014) Thieno[2,3-d]pyrimidine-2-carboxamides bearing a carboxybenzene group at 5-position: highly potent, selective, and orally available MMP-13 inhibitors interacting with the S1 binding site. Bioorg.Med.Chem. 22 5487 PMID:25192810

4'-alpha-C-Allyl-2',3'-bis(O-t-butyldimethylsilyl)uridine is a Nucleoside Derivative - 4'-Modified nucleoside; Protected nucleoside w/NH2/OH open.

Nucleoside Derivative –4’-Modified nucleosides; Protected nucleosides with NH2/OH group

3',5'-Bis(O-t-butyldimethylsilyl)-4'-C-hydroxymethyl thymidine is a Nucleoside Derivative - 4'-Modified nucleoside; Protected nucleoside w/NH2/OH open.

3'-O-t-Bulyldimethylsilyl-4'-C-hydroxymethylthymidine is a Nucleoside Derivative - 4'-Modified nucleoside.

Nucleoside Derivatives - 4’-Modified nucleosides; Azido nucleosides; Protected nucleosides w/NH2/OH open

A-893 is a cell-active inhibitor of Methyltransferase SMYD2 (IC50 = 2.8 nM).