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T-705RMP
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Catalog No. T40447Cas No. 356783-08-9
T-705RMP, the phosphorylated metabolite derived from T-705, demonstrates a limited inhibitory impact on the host cells' IMP dehydrogenase (IMPDH) activities, with an IC 50 value of 601 μM.
T-705RMP
😃Good
Catalog No. T40447Cas No. 356783-08-9
T-705RMP, the phosphorylated metabolite derived from T-705, demonstrates a limited inhibitory impact on the host cells' IMP dehydrogenase (IMPDH) activities, with an IC 50 value of 601 μM.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 25 mg | $1,520 | Backorder |
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Product Introduction
Bioactivity
Chemical Properties
| Description | T-705RMP, the phosphorylated metabolite derived from T-705, demonstrates a limited inhibitory impact on the host cells' IMP dehydrogenase (IMPDH) activities, with an IC 50 value of 601 μM. |
| In vitro | T-705 undergoes phosphorylation by cellular kinases to form T-705RMP and T-705RTP; enzymes within the host cell can distinguish between T-705, its phosphorylated forms (T-705RMP and T-705RTP), and natural nucleotides. Notably, T-705RMP inhibits IMPDH approximately 150-fold less effectively than Ribavirin monophosphate, indicating that T-705's antiviral activity does not stem from inhibiting this cellular enzyme[1]. |
| Molecular Weight | 369.198 |
| Formula | C10H13FN3O9P |
| Cas No. | 356783-08-9 |
| Relative Density. | 2.22 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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