T0467 is a chemical compound that activates the translocation of parkin to the mitochondria in a PINK1-dependent manner in vitro. However, T0467 does not induce the accumulation of PINK1 in the mitochondria of dopaminergic neurons. As a result, T0467 shows promise as a potential compound for activating the PINK1-Parkin signaling pathway and can be utilized in research related to Parkinson's disease and related disorders.

T0467 (2.5-20 μM; 3 hours) induces mitochondrial translocation of GFP-Parkin in HeLa/GFP-Parkin cells, with significant effects at concentrations above 12 μM [1]. At 20 μM, 21% of cells show translocation [1]. Non-toxic below 50 μM in Drosophila, T0467 mitigates defects in larval locomotion, mitochondrial morphology, and ATP production associated with PINK1 inactivation, and enhances mitochondrial Ca2+ response in Drosophila larval muscles [1].