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TAK-683

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Catalog No. TP2156LCas No. 872719-49-8

TAK-683 is an effective full KISS1 receptor agonist (IC50=170 pM). TAK-683 is a nonapeptide metastin analog, shows agonistic activities to KISS1R (EC50: 0.96 nM and 1.6 nM for human and rat, respectively).

TAK-683
Other Forms of TAK-683:

TAK-683

😃Good
Catalog No. TP2156LCas No. 872719-49-8
TAK-683 is an effective full KISS1 receptor agonist (IC50=170 pM). TAK-683 is a nonapeptide metastin analog, shows agonistic activities to KISS1R (EC50: 0.96 nM and 1.6 nM for human and rat, respectively).
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Product Introduction

Bioactivity
Description
TAK-683 is an effective full KISS1 receptor agonist (IC50=170 pM). TAK-683 is a nonapeptide metastin analog, shows agonistic activities to KISS1R (EC50: 0.96 nM and 1.6 nM for human and rat, respectively).
Targets&IC50
KISS1R:170 pM
In vitro
In rat KISS1R-expressing Chinese hamster ovary cells, TAK-683 exhibits an IC50 value (95% CI) from receptor binding assays is 150-180 pM and EC50 value (95% CI) from Ca+ mobilization assays is 180 (159–203) pM [4].
In vivo
TAK-683 (subcutaneous injection; 0.008, 0.08, 0.8, or 8 μmol/ml/kg; once daily; 7 days) initially increases plasma luteinizing hormone and testosterone levels, but reduces plasma hormones and genital organ weights after 7 days. In a prostate cancer model with TAK-683 (subcutaneous injection; 2.1-21 nmol/kg/day; once daily; 12 weeks), serum PSA concentrations decrease below detection levels (0.5 ng/ml) in all rats by day 14. TAK-683 (subcutaneous injection; 10, 30, or 100 pmol/h; once daily; 4 weeks) shows promise in suppressing reproductive functions and hormone-related diseases such as prostate cancer [3][4].
Chemical Properties
Molecular Weight1298.45
FormulaC64H83N17O13
Cas No.872719-49-8
Relative Density.no data available
Storage & Solubility Information
Storagekeep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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Keywords

TAK683TAK-683TAK 683
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