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Tankyrase Inhibitors (TNKS) 49
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Catalog No. T23419
Tankyrase Inhibitors 49 is an effective, selective, and orally bioavailable inhibitor of tankyrase (IC50: 0.1nM).
Tankyrase Inhibitors (TNKS) 49
😃Good
Catalog No. T23419
Tankyrase Inhibitors 49 is an effective, selective, and orally bioavailable inhibitor of tankyrase (IC50: 0.1nM).
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 5 mg | $189 | Backorder | |
| 10 mg | $329 | Backorder | |
| 50 mg | $888 | Backorder | |
| 100 mg | $1,400 | Backorder | |
| 1 mL x 10 mM (in DMSO) | $273 | Backorder |
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Product Introduction
Bioactivity
Chemical Properties
| Description | Tankyrase Inhibitors 49 is an effective, selective, and orally bioavailable inhibitor of tankyrase (IC50: 0.1nM). |
| In vitro | Tankyrase inhibitors 49 is an optimization of the previous hit compound inhibitor 8 with improved potency and selectivity. It has excellent effects in both tankyrase assay and cellular assay (IC50: 0.1nM and 1.9nM, respectively). In addition, it is found to be a dual binder with both the nicotinamide pocket and the induced pocket of the enzymes [1]. |
| In vivo | In the in vivo studies in rodents, tankyrase inhibitors 49 is found to potently inhibit TNKS2 autoparsylation ( IC50: 7.6nM). It also causes stabilization and accumulation of axin protein in SW480 cells (EC50: 4nM). In DLD-1 cells with truncated APC, the inhibitor inhibits the STF reporter transcription ( IC50: 0.3nM) suggesting its downstream inhibitory activity on Wnt-associated transcription [1]. |
| Molecular Weight | 448.54 |
| Formula | C24H24N4O3S |
| Relative Density. | no data available |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO: ≥22.45 mg/mL |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
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Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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