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Tarazepide

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Catalog No. T13084Cas No. 141374-81-4

Tarazepide is a potent and specific antagonist of the CCK-A receptor.

Tarazepide

Tarazepide

😃Good
Catalog No. T13084Cas No. 141374-81-4
Tarazepide is a potent and specific antagonist of the CCK-A receptor.
Pack SizePriceAvailabilityQuantity
25 mg$2,120 8-10 weeks
50 mg$2,780 8-10 weeks
100 mg$3,700 8-10 weeks
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Product Introduction

Bioactivity
Description
Tarazepide is a potent and specific antagonist of the CCK-A receptor.
In vivo
duodenal electric activity decreased by Tarazepide, reduces interdigestive pancreatic secretion, especially protein; reduces cephalic and early postprandial (milk) induced secretion of bicarbonate and protein.Pancreatic protein secretion to intravenous CCK-8 was little affected by atropine, but was significantly reduced by Tarazepide±Atropine; in contrast, protein secretion to intraduodenal CCK-8 was abolished by Tarazepide or atropine[1]. Leptin is administered to the animals at doses of 0.1, 1.0 or 10.0 μg/kg i.d. Tarazepide (2.5 mg/kg, i.d.), a CCK(1) receptor antagonist, is given to the rats prior to the application of leptin. CCK plasma level is measured by radioimmunoassay (RIA) following administration of leptin to the rats. Intraduodenal administration of leptin (1.0 or 10.0 microg/kg) to the fasted rats significantly and dose-dependently increases pancreatic protein and amylase outputs. Capsaicin inactivates sensory nerves or pretreatment with taracidide completely eliminates pancreatic secretory response to leptin[2].
Chemical Properties
Molecular Weight448.52
FormulaC28H24N4O2
Cas No.141374-81-4
Relative Density.no data available
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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