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TAT-PiET

Catalog No. TP2673Cas No. 3036046-03-1

TAT-PiET, a cell-penetrating peptide, targets the extra-terminal (ET) domain of BRD4, disrupting the critical BRD4/JMJD6 protein complex interaction necessary for oncogene expression in breast cancer. By inhibiting BRD4/JMJD6 target gene expression, TAT-PiET effectively suppresses breast cancer cell growth and confers resistance to endocrine therapy in ERα-positive breast cancer cells, marking it as a potential inhibitor of breast cancer.

TAT-PiET

TAT-PiET

Catalog No. TP2673Cas No. 3036046-03-1
TAT-PiET, a cell-penetrating peptide, targets the extra-terminal (ET) domain of BRD4, disrupting the critical BRD4/JMJD6 protein complex interaction necessary for oncogene expression in breast cancer. By inhibiting BRD4/JMJD6 target gene expression, TAT-PiET effectively suppresses breast cancer cell growth and confers resistance to endocrine therapy in ERα-positive breast cancer cells, marking it as a potential inhibitor of breast cancer.
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Product Introduction

Bioactivity
Description
TAT-PiET, a cell-penetrating peptide, targets the extra-terminal (ET) domain of BRD4, disrupting the critical BRD4/JMJD6 protein complex interaction necessary for oncogene expression in breast cancer. By inhibiting BRD4/JMJD6 target gene expression, TAT-PiET effectively suppresses breast cancer cell growth and confers resistance to endocrine therapy in ERα-positive breast cancer cells, marking it as a potential inhibitor of breast cancer.
Chemical Properties
Molecular Weight2651.07
FormulaC110H192N48O27S
Cas No.3036046-03-1
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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