Shopping Cart

Remove All
Your shopping cart is currently empty

tBID

Name: tBID
Brand: TargetMol
SKU: T13096
Rating: 4.5 (1 reviews)

😃Good

Catalog No. T13096Cas No. 1639895-85-4

tBID is a selective homeodomain-interacting protein kinase 2 (HIPK2) inhibitor (IC50 of 0.33 μM)

tBID

😃Good

Catalog No. T13096Cas No. 1639895-85-4

tBID is a selective homeodomain-interacting protein kinase 2 (HIPK2) inhibitor (IC50 of 0.33 μM)

Pack Size	Price	Availability
5 mg	$347	6-8 weeks
25 mg	$1,140	6-8 weeks
50 mg	$1,490	6-8 weeks
100 mg	$1,990	6-8 weeks
1 mL x 10 mM (in DMSO)	$395	6-8 weeks

Bulk & Custom

Add to Cart

Questions

Resource Download

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Product Introduction

Bioactivity

Description	tBID is a selective homeodomain-interacting protein kinase 2 (HIPK2) inhibitor (IC50 of 0.33 µM)
Targets&IC50	HIPK2:0.33 µM
In vitro	Homeodomain-interacting protein kinase 2 (HIPK2) is a Ser/Thr kinase that regulates cell proliferation and survival. TBID exhibits exceptional efficacy against HIPK2 with an IC50 of 0.33 μM and a Gini coefficient of 0.592 out of a panel of 76 kinases. Although TBID also inhibits HIPK1 and HIPK3, it is less effective against these kinases. TBID acts competitively with ATP, consistent with modeling, and interacts with the hinge region through hydrophobic interactions with Val 213, Val 261, Phe 277, Leu 280, Met 331, and Ile 345, while the symmetric nitrogen atom at position 3 engages with the catalytic Lys 228, playing a crucial role in binding architecture.

Chemical Properties

Molecular Weight	528.78
Formula	C₁₁H₃Br₄N₃O₂
Cas No.	1639895-85-4
Relative Density.	2.604 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 26 mg/mL (49.17 mM), Sonication and heating are recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.8911 mL	9.4557 mL	18.9115 mL	94.5573 mL
5 mM	0.3782 mL	1.8911 mL	3.7823 mL	18.9115 mL
10 mM	0.1891 mL	0.9456 mL	1.8911 mL	9.4557 mL
20 mM	0.0946 mL	0.4728 mL	0.9456 mL	4.7279 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

tBIDHIPK2