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Pack Size | Price | Availability | Quantity |
---|---|---|---|
500 μg | $297 | Backorder | |
1 mg | $592 | Backorder | |
5 mg | $1,970 | Backorder |
Description | TC 14012, a peptidomimetic compound, acts as both an antagonist to the chemokine (C-X-C motif) receptor 4 (CXCR4; IC50 = 2.9 nM) and as an agonist for CXCR7, effectively recruiting β-arrestin in HEK293T cells that express CXCR7 (EC50 = 350 nM). Moreover, it demonstrates significant antiviral activity by reducing the cytopathic effects of HIV in MT-4 cells with an EC50 value of 0.4 nM and inhibiting HIV entry in vitro through a CXCR4-dependent pathway (IC50 = 19.3 nM). Additionally, TC 14012 suppresses chemokine (C-X-C motif) ligand 12 (CXCL12)-induced migration in MDA-MB-231 breast cancer and human umbilical vein endothelial cells (HUVECs) within the 10 to 1,000 nM concentration range. In a mouse model, administration of TC 14012 at 10 mg/kg significantly reduced infarct size following acute myocardial infarction induced by ligation of the left anterior descending (LAD) coronary artery. |
Alias | H-Arg-Arg-Nal-Cys-Tyr-Cit-Lys-D-Cit-Pro-Tyr-Arg-Cit-Cys-Arg-NH2 |
Molecular Weight | 2066.42 |
Formula | C90H140N34O19S2.XHCl |
Cas No. |
Storage | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
Solubility Information | PBS pH 7.2: 10 mg/ml DMSO: 10 mg/ml |
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