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TCRS-417

Name: TCRS-417
Brand: TargetMol
SKU: T81027
Price: 126 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T81027Cas No. 2032123-28-5

Alias TCRS417, T417, T 417

TCRS-417 (T417) inhibits PBX1-DNA interaction in mammalian cells or cell clusters, used in autoimmune and neurodegenerative disease research.

TCRS-417

🥰Excellent

Catalog No. T81027Alias TCRS417, T417, T 417Cas No. 2032123-28-5

TCRS-417 (T417) inhibits PBX1-DNA interaction in mammalian cells or cell clusters, used in autoimmune and neurodegenerative disease research.

Pack Size	Price	Availability
1 mg	$126	In Stock
5 mg	$368	In Stock
10 mg	$578	In Stock

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COA

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Product Introduction

Bioactivity

Description	TCRS-417 (T417) inhibits PBX1-DNA interaction in mammalian cells or cell clusters, used in autoimmune and neurodegenerative disease research.
In vitro	TCRS-417 (0 μM, 2.5 μM, 5 μM, 7.5 μM and 10 μM, 48h) can effectively interfere with PBX1-DNA interactions. [1]
In vivo	TCRS-417(2.5 mg/kg intraperitoneally injected) inhibited tumor growth in mice xenografted with SKOV3CRLuc. [1]
Alias	TCRS417, T417, T 417

Chemical Properties

Molecular Weight	446.43
Formula	C₂₅H₁₉FN₂O₅
Cas No.	2032123-28-5
Smiles	O=C(NC1=CC=C(OCC(=O)NC2=CC=C(O)C(O)=C2)C=3C=CC=CC13)C=4C=CC=C(F)C4

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 80 mg/mL (179.2 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2400 mL	11.2000 mL	22.3999 mL	111.9996 mL
5 mM	0.4480 mL	2.2400 mL	4.4800 mL	22.3999 mL
10 mM	0.2240 mL	1.1200 mL	2.2400 mL	11.2000 mL
20 mM	0.1120 mL	0.5600 mL	1.1200 mL	5.6000 mL
50 mM	0.0448 mL	0.2240 mL	0.4480 mL	2.2400 mL
100 mM	0.0224 mL	0.1120 mL	0.2240 mL	1.1200 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc