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Thailanstatin D

Name: Thailanstatin D
Brand: TargetMol
SKU: T39071
Price: 36 USD
Availability: InStock
Rating: 4.5 (1 reviews)

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Catalog No. T39071Cas No. 1609105-89-6

Thailanstatin D, an analogue of Thailanstatin A, inhibits AR-V7 gene splicing by disrupting the interaction between U2AF65 and SAP155, hindering their binding to the polypyrimidine tract situated between the branch point and the 3' splice site. This compound displays potent tumor inhibitory properties in human castration-resistant prostate cancer (CRPC) xenografts, resulting in cellular apoptosis.

Thailanstatin D

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Catalog No. T39071Cas No. 1609105-89-6

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Product Introduction

Bioactivity

Description	Thailanstatin D, an analogue of Thailanstatin A, inhibits AR-V7 gene splicing by disrupting the interaction between U2AF65 and SAP155, hindering their binding to the polypyrimidine tract situated between the branch point and the 3' splice site. This compound displays potent tumor inhibitory properties in human castration-resistant prostate cancer (CRPC) xenografts, resulting in cellular apoptosis.
In vitro	Thailanstatin D (0-50 nM; 4 hours) significantly reduces AR-V7 and other AR splice variants (AR-Vs)[1] protein levels and dose-dependently suppresses mRNA levels of AR-V7 and AR-FL in VCaP, 22RV1, and LN95 cell lines, as observed in a Cell Viability Assay[1].
In vivo	Thailanstatin D, administered at a dosage of 300 μg/kg through ALZET osmotic pumps daily for four days, significantly inhibited tumor growth in an animal model of NOD-SCID mice bearing 22RV1 xenografts.

Chemical Properties

Molecular Weight	519.635
Formula	C₂₈H₄₁NO₈
Cas No.	1609105-89-6
Relative Density.	1.19 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

Thailanstatin D