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Thalidomide-5,6-F is a cereblon ligand derived from Thalidomide that is utilized for the recruitment of CRBN protein. It can be conjugated to a protein ligand through a linker, thus enabling the formation of PROTACs, a class of molecules with targeted protein degradation capabilities.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
500 mg | 142 € | 7-10 days |
Description | Thalidomide-5,6-F is a cereblon ligand derived from Thalidomide that is utilized for the recruitment of CRBN protein. It can be conjugated to a protein ligand through a linker, thus enabling the formation of PROTACs, a class of molecules with targeted protein degradation capabilities. |
In vitro | PROTACs consist of two distinct ligands connected by a linker: one ligand targets an E3 ubiquitin ligase, and the other targets the desired protein. They leverage the intracellular ubiquitin-proteasome system to selectively degrade target proteins [1]. |
Molecular Weight | 294.21 |
Formula | C13H8F2N2O4 |
Cas No. | 1496997-41-1 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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