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Thalidomide-Piperazine-Piperidine hydrochloride is a synthesized compound serving as an E3 ligase ligand-linker conjugate, combining the cereblon ligand derived from Thalidomide with a linker commonly used in PROTAC technology.
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Description | Thalidomide-Piperazine-Piperidine hydrochloride is a synthesized compound serving as an E3 ligase ligand-linker conjugate, combining the cereblon ligand derived from Thalidomide with a linker commonly used in PROTAC technology. |
In vitro | PROTACs are composed of two distinct ligands joined by a linker; one ligand targets an E3 ubiquitin ligase while the other targets the protein of interest. They utilize the intracellular ubiquitin-proteasome system to selectively degrade target proteins [1]. |
Molecular Weight | 461.95 |
Formula | C22H28ClN5O4 |
Cas No. | 2599846-44-1 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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