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Pack Size | Price | Availability | Quantity |
---|---|---|---|
25 mg | $767 | 6-8 weeks | |
50 mg | $997 | 6-8 weeks | |
100 mg | $1,540 | 6-8 weeks |
Description | Thienopyridone is a potent and selective inhibitor of phosphatase of regenerating liver (PRL) phosphatase(IC50s of 173 nM, 277 nM and 128 nM for PRL-1, PRL-2, and PRL-3, respectively), and induces p130Cas cleavage and apoptosis and has anticancer effects. |
In vitro | in soft agar, Thienopyridone shows significant inhibition of tumor cell anchorage-independent growth (EC50 of the Thienopyridone are 3.29 μM and 3.05 μM for RKO and HT-29 cells, respectively). Thienopyridone (1-75 μM; 24 hours; HeLa cells) treatment shows a dose-dependent down-regulation of total p130Cas in HeLa cells. Thienopyridone induces p130Cas and FAK cleavage leads to caspase-mediated cell apoptosis. the cleavage of PARP and caspase-8 induced by Thienopyridone. Thienopyridone (3.75-30 μM; 24 hours) significantly suppresses HUVEC migration but not proliferation. |
Molecular Weight | 242.3 |
Formula | C13H10N2OS |
Cas No. | 1018454-97-1 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
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