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Description | Thiol-PEG3-acid, a PEG-based linker for PROTACs, facilitates the connection of two essential ligands to form PROTAC molecules, enabling selective protein degradation through the ubiquitin-proteasome system within cells. |
In vitro | PROTACs consist of two ligands joined by a linker: one binds to an E3 ubiquitin ligase, and the other targets a specific protein. They harness the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. |
Molecular Weight | 238.3 |
Formula | C9H18O5S |
Cas No. | 1347750-82-6 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
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