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Description | Thiol-PEG4-alcohol is a PEG-based linker for PROTACs that connects two essential ligands, facilitating the formation of PROTAC molecules and enabling selective protein degradation through the ubiquitin-proteasome system within cells. |
In vitro | PROTACs, which consist of two ligands joined by a linker—one targeting an E3 ubiquitin ligase and the other a target protein—utilize the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. |
Alias | HS-PEG4-OH |
Molecular Weight | 210.29 |
Formula | C8H18O4S |
Cas No. | 90952-27-5 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
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