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Thiophene-2

Name: Thiophene-2
Brand: TargetMol
SKU: T40520
Price: 58 USD
Availability: InStock
Rating: 4.5 (1 reviews)

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Catalog No. T40520Cas No. 420089-51-6

Alias TP2, Thiophene-2

Thiophene-2 (TP2) is a targeted inhibitor of polyketide synthase 13 (Pks13), specifically designed to disrupt mycolic acid biosynthesis, effectively inducing rapid cell death in mycobacteria. It demonstrates notable anti-tuberculosis activity and exhibits a minimum inhibitory concentration (MIC) value of 1 μM against Mycobacterium tuberculosis.

Thiophene-2

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Catalog No. T40520Alias TP2, Thiophene-2Cas No. 420089-51-6

Pack Size	Price	Availability	Quantity
5 mg	$970	Backorder

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Product Introduction

Bioactivity

Description	Thiophene-2 (TP2) is a targeted inhibitor of polyketide synthase 13 (Pks13), specifically designed to disrupt mycolic acid biosynthesis, effectively inducing rapid cell death in mycobacteria. It demonstrates notable anti-tuberculosis activity and exhibits a minimum inhibitory concentration (MIC) value of 1 μM against Mycobacterium tuberculosis.
Targets&IC50	Mycobacterium tuberculosis:1 μM (MIC)
In vitro	In vitro, TP inhibits the fatty acyl-AMP's ability to bind with Pks13, and Thiophene-2 (TP2; 0-125 μM) demonstrates a dose-dependent inhibition of this activity in both wild-type Mycobacterium tuberculosis (Mtb) Pks13 (Pks13_WT) and the TP-resistant F79S mutant protein, specifically affecting palmitic acid (FL C16) loading. Furthermore, Thiophene-2 exhibits significant cytotoxic activity, with an IC50 of 17.5 μM against monkey kidney Vero cells and 7.30 μM against human liver carcinoma HepG2 cells. Notably, it also shows considerable intracellular killing capacity within BCG-infected J774A.1 macrophage cells at concentrations of 12.8 μM[1].
Alias	TP2, Thiophene-2

Chemical Properties

Molecular Weight	419.37
Formula	C₁₈H₁₄F₅NO₃S
Cas No.	420089-51-6

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

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Keywords

Thiophene 2TP 2Thiophene2TP-2