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TM38837

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Purity:100%

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COA LCMS HNMR

TM38837

Catalog No. T8511Cas No. 1253641-65-4

TM38837 is an antagonist of cannabinoid receptor type 1 (CB1), with potential for the treatment of obesity and type 2 diabetes.

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Pack Size	Price	Availability
1 mg	$55	In Stock
5 mg	$126	In Stock
10 mg	$166	In Stock
25 mg	$287	In Stock
50 mg	$450	In Stock
100 mg	$663	In Stock
1 mL x 10 mM (in DMSO)	$166	In Stock

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Related Compound Libraries of "TM38837"

Product Introduction

Bioactivity

Description

TM38837 is an antagonist of cannabinoid receptor type 1 (CB1), with potential for the treatment of obesity and type 2 diabetes.

In vivo

TM38837, a novel, largely peripherally restricted CB1 antagonist, in terms of fear-promoting consequences of systemic vs. intracerebral injections.?Different groups of male C57BL/6 N mice underwent auditory fear conditioning, followed by re-exposure to the tone.?Mice were treated per os (p.o.) with TM38837 (10, 30, or 100 mg/kg), rimonabant (10 mg/kg;?a brain penetrating CB1 antagonist/inverse agonist which served as a positive control), or vehicle, 2 h prior the tone presentation.?Only the high dose of TM38837 (100 mg/kg) induced a significant increase in freezing behavior, similar to that induced by rimonabant (10 mg/kg) (p

Chemical Properties

Molecular Weight	617.51
Formula	C30H25Cl2F3N4OS
Cas No.	1253641-65-4

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 40 mg/mL (64.77 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.6194 mL	8.0970 mL	16.1941 mL	80.9703 mL
5 mM	0.3239 mL	1.6194 mL	3.2388 mL	16.1941 mL
10 mM	0.1619 mL	0.8097 mL	1.6194 mL	8.0970 mL
20 mM	0.0810 mL	0.4049 mL	0.8097 mL	4.0485 mL
50 mM	0.0324 mL	0.1619 mL	0.3239 mL	1.6194 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

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DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

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