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TMC647055 Choline salt

Name: TMC647055 Choline salt
Brand: TargetMol
SKU: T13170
Rating: 4.5 (1 reviews)

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Catalog No. T13170

TMC647055 choline salt is a selective and cell-permeating inhibitor of HCV NS5B (IC50: 34 nM).

TMC647055 Choline salt

😃Good

Catalog No. T13170

TMC647055 choline salt is a selective and cell-permeating inhibitor of HCV NS5B (IC50: 34 nM).

Pack Size	Price	Availability
2 mg	$179	Backorder
5 mg	$267	Backorder
10 mg	$398	Backorder
50 mg	$1,146	Backorder
100 mg	$1,850	Backorder
200 mg	Inquiry	Backorder
500 mg	Inquiry	Backorder
1 mL x 10 mM (in DMSO)	$426	Backorder

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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Product Introduction

Bioactivity

Description

TMC647055 choline salt is a selective and cell-permeating inhibitor of HCV NS5B (IC50: 34 nM).

In vitro

TMC647055 is a novel and potent nonnucleoside the HCV NS5B RNA-dependent RNA polymerase inhibitor. TMC647055 shows high selectivity for HCV when evaluated with a broad panel of human DNA and RNA viruses. TMC647055 shows median EC50 changes in the replicon assay of 9-, 3-, and 371-fold for L392I, V494A, and P495L, respectively, The median EC50 of TMC647055 on NS5B sequences derived from clinical isolates of genotypes 1a, 1b, 3a, 4a, and 6a ranged between 27 nM and 113 nM.

Chemical Properties

Molecular Weight	727.91
Formula	C₃₇H₅₃N₅O₈S
Relative Density.	1.31g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 43 mg/mL (59.07 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.3738 mL	6.8690 mL	13.7380 mL	68.6898 mL
5 mM	0.2748 mL	1.3738 mL	2.7476 mL	13.7380 mL
10 mM	0.1374 mL	0.6869 mL	1.3738 mL	6.8690 mL
20 mM	0.0687 mL	0.3434 mL	0.6869 mL	3.4345 mL
50 mM	0.0275 mL	0.1374 mL	0.2748 mL	1.3738 mL

Calculator

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

TMC647055 Choline saltTMC647055 CholineTMC-647055 Choline salt