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TMP778

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Catalog No. T13172LCas No. 1422053-04-0

TMP778 is an effective and selective RORγt inverse agonist (IC50: 7 nM in FRET assay).

TMP778

TMP778

😃Good
Catalog No. T13172LCas No. 1422053-04-0
TMP778 is an effective and selective RORγt inverse agonist (IC50: 7 nM in FRET assay).
Pack SizePriceAvailabilityQuantity
25 mg$1,6208-10 weeks
50 mg$2,1108-10 weeks
100 mg$3,1008-10 weeks
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Product Introduction

Bioactivity
Description
TMP778 is an effective and selective RORγt inverse agonist (IC50: 7 nM in FRET assay).
Targets&IC50
FRET assay:7 nM, Th17 cells:0.03 μM , IL-17F promoter assay:63 nM, Tc17 cells:0.005 μM (in Tc17 cells)
Chemical Properties
Molecular Weight494.58
FormulaC31H30N2O4
Cas No.1422053-04-0
Relative Density.no data available
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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