Powder: -20°C for 3 years | In solvent: -80°C for 1 year
TMX-4116 is a casein kinase 1α ( CK1α ) degrader. TMX-4116 shows the degradation preference for CK1α with DC 50 s less than 200 nM in MOLT4, Jurkat, and MM.1S cells. TMX-4116 can be used for the research of multiple myeloma [1] .
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
25 mg | 10-14 weeks | $ 1,650.00 | |
50 mg | 10-14 weeks | $ 2,150.00 | |
100 mg | 10-14 weeks | $ 3,310.00 |
Description | TMX-4116 is a casein kinase 1α ( CK1α ) degrader. TMX-4116 shows the degradation preference for CK1α with DC 50 s less than 200 nM in MOLT4, Jurkat, and MM.1S cells. TMX-4116 can be used for the research of multiple myeloma [1] . |
In vitro | TMX-4116 (compound 16; 1 μM; 4 h) shows a high degradation preference for CK1α in MOLT4 cells [1]. TMX-4116 (250 nM, 4 h) induces primary target degradation of CK1α, while no downregulation of PDE6D, IKZF1, and IKZF3 in MOLT4 cells [1]. Western Blot Analysis [1] Cell Line: MOLT4 cells Concentration: 1 μM Incubation Time: 4 hours Result: Showed a high degradation preference for CK1α. Western Blot Analysis [1] Cell Line: MOLT4, Jurkat, and MM.1S cells Concentration: 0 nM, 40 nM, 200 nM, 1 μM Incubation Time: 4 hours Result: Showed a high degradation preference for CK1α with the DC 50 value less than 200 nM in MOLT4, Jurkat, and MM.1S cells. |
Molecular Weight | 389.43 |
Formula | C17H19N5O4S |
CAS No. | 2766385-56-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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TMX-4116 2766385-56-0 inhibitor inhibit